Roger B. Knowles

Co-Director of Neurosciences Major
Assistant Professor of Biology
Drew University
Hall of Sciences 128
Madison, NJ 07940
Phone: (973) 408-3561
email: rknowles@drew.edu

Neurobiology Home Page



 
 
Courses
Biol 2: Biology of the Mind

 
Personal Information Cool Images
Education Senile Plaque from an AD brain
B.S., 1986, West Point Neuronal and Glial Cells grown in culture
Ph.D. in Neuroscience, 1996, Harvard University Neurofibrillary Tangle from an AD brain

    Research Interests
        The three pathological hallmarks of Alzheimer’s Disease are extracellular senile plaques, intracellular neurofibrillary tangles, and a profound loss of neurons and functional neuronal connections. Recent evidence suggests that there is a connection between these pathologic events. However, the pathways that link the extracellular deposits and the intracellular
dystrophies are unclear. In our laboratory, students choose research projects that focus on trying to elucidate these pathways.

Here are examples of the kind of projects in which students may participate:
1. Examine effect of senile plaque components on neuronal trafficking of organelles.
2. Measure changes in cytoskeleton stability of neurons due to stimulation from factors present in senile plaques.
3. Test neurotransmitter receptor efficiency in neuronal cultures treated with factors present in senile plaques.
4. Manipulate intracellular signaling cascades in neuronal cultures to test specific pathways being activated in senile plaques.

    Publications
2003 Alzheimer's Disease. Prentice-Hall, Inc.
2001 Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer Disease: Implications for neural system disruption. Journal of Neuropathology and Experimental Neurology 60: 753-758.
2000 Microtubule-Affinity Regulating Kinase (MARK) is tightly associated with Neurofibrillary Tangles in Alzheimer's brain: A fluorescence resonance energy transfer study. Journal of Neuropathology and Experimental Neurology 59: 966-971.
2000 Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astorcytes: in vitro ERK1/2 activation and role in Alzheimer's disease. Journal of Neuroimmunology 108: 227-235.
1999 Demonstration by fluorescence energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: Implications for MAP kinase activation in Alzheimer’s disease. Journal of Neuropathology and Experimental Neurology 58: 1090-1098.
1999 The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Molecular Brain Research 69: 273-280.
1999   Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuoroscience 93: 433-439.
1999   Plaque-Induced Neurite Abnormalities: Implications for Disruption of Neural Networks in Alzheimer’s Disease. Proceedings National Academy of Science USA, 96: 5274-5279.
1998   Aß Associated Neuropil Changes: Correlation with Neuronal Loss and Dementia. Journal of Neuropathology and Experimental Neurology 57: 1122-1130.
1998   Statistical physics and Alzheimer's disease. Physica A 249: 1-4.
1998   Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Experimental Neurology 149: 175-182.
1997   Neurotrophin-3 signals redistributes RNA in neurons. Proceedings of National Academy of Science USA 94: 14804-14808.
1997   Heparin Sulfate labeling in neocortex of Alzheimer’s disease patients. Journal of Neuropathology and Experimental Neurology 56: 575.
1996   Translocation of RNA granules in living neurons. Journal of Neuroscience 16: 7812-7820.
1995   Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. in Alzheimer's Disease: Lessons from Cell Biology. Springer-Verlag, Berlin, Germany
1994   Organization of actin and microtubules during process formation in tau-expressing Sf9 cells. Cell Motility and the Cytoskeleton 28: 256-264
1994   Beta-Adrenergic receptor mediated regulation of extracellular adenosine in cerebral cortex in culture. Journal of Neuroscience 14: 2953-2965.
1993   Conservation of the amino acid sequence of SV2, a transmembrane transporter in synaptic vesicles and endocrine cells. Gene 137: 299-302.













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